Concepts, mathematical models and software for theoretical study of general rules determining human organism responses to alterations of environmental physical-chemical characteristics are proposed. The software modeling complex (SMC) includes 5 models: 1) Mechanism of reactive cell adaptation to induced energy deficit (IED); 2) Mechanism of main physiological systems integration for IED minimization in a group of cells; 3) Mechanisms of physical changes and physiological responses of cardiovascular system and kidney under atmosphere pressure changes; 4) Mechanism of thermoregulatory responses to IED; 5) Model of external environmental characteristics. Technology of SMC usage is illustrated in test examples.