Another concept of the life origin and evolutionary complication based on principle of self-organization needs not any goals and their creators. This alternative concept is able to interpret the most of regulator processes in multi-celled organisms using specific producer-user (PU) type of relationships. Principle differences between natural and known artificial control systems are connected with two characteristics of living cells: 1. Each living cell has a property to self-adapt its rate of biosynthesis in accordance with the increased rate of its structuralenergetic losses; 2. Each living cell is functioning discretely.

The proposed view of systemic relationships in multi-celled organisms allowed us to interpret internal mechanism of wide spread biological nonlinearity. The nonlinear dependence between multi-celled organs is determined by cells parallel but asynchronous activity.

Mathematical models created using these basic organizational principles allow one to systemic analyze and to quantitative describe human organism adaptation to different environmental changes including gravitational, thermal, barometric, oxygen and others.